Dermasim VT 500 Tablet

Uses of Dermasim VT 500

• Fungal infections

How does Dermasim VT 500 work?

Dermasim VT 500 Tablet works by preventing fungal growth. Clotrimazole works by blocking the production of enzymes responsible for the growth of fungal cells. This inhibition results in the breakage of cell membranes and fungal cell abnormalities, finally leading to alterations in the membrane-based activity of fungus. These lead to fungal cell death and the prevention of further fungal growth.

Side Effects of Dermasim VT 500

• Vaginal burning
• Vaginal itching
• Vaginal redness or pain
• Lower abdominal cramps/pain

Quick Suggestions:

• Dermasim VT 500  helps treat vaginal fungal infections. It reduces vaginal burning, itching, and discharge.
• Do not skip any doses and finish the full course of treatment even if you feel better.
• It is inserted into the vagina using an applicator, usually at night before going to bed.
• Avoid contact with your eyes. If accidental exposure occurs, rinse immediately with plenty of water.
• It can damage condoms and diaphragms and make them ineffective at preventing pregnancy. Ask your doctor about other suitable methods of preventing pregnancy.
• It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
• Inform your doctor if your symptoms do not get improved within 3 days of taking the medicine.

Indication of Dermasim VT 500

Vaginal Candidiasis, also known as vulvovaginal candidiasis or vaginal yeast infection is a fungal infection of the vagina. The symptoms may include vaginal swelling and itchiness, white discharge from the vagina, pain or discomfort during urination, etc. Dermasim VT 500 is used in the treatment of vaginal candidiasis.

Pharmacology

Clotrimazole is an antifungal medication that works by targeting the cell membrane of fungi, specifically inhibiting the synthesis of ergosterol, a crucial component of the fungal cell membrane. Ergosterol is necessary for maintaining the integrity and function of the cell membrane in fungi.

When clotrimazole blocks the formation of ergosterol, the fungal cell's permeability barrier weakens, leading to the disruption of the cell membrane structure. As a result, the fungal cell becomes unable to maintain its structural integrity and normal function, ultimately leading to cell death.

The inhibition of ergosterol synthesis is primarily achieved by targeting an enzyme called lanosterol 14-demethylase (also known as CYP51), which is involved in the biosynthesis of ergosterol. By blocking this enzyme, clotrimazole interferes with the conversion of lanosterol into ergosterol, leading to reduced levels of ergosterol in the fungal cell.

Apart from its effect on ergosterol synthesis, clotrimazole also exhibits additional pharmacological effects that contribute to its antifungal activities. These include blocking calcium-dependent potassium channels, inhibiting sarcoplasmic reticulum Ca2+ ATPase, and depleting intracellular calcium. These actions further contribute to the disruption of fungal cell function and growth.

Clotrimazole's multifaceted mechanisms of action make it an effective antifungal agent in the treatment of candidal vaginitis and other fungal infections. As with any medication, it's essential for patients to use clotrimazole as directed by their healthcare provider and be aware of any potential side effects or drug interactions. If there are any concerns or adverse reactions, patients should seek medical attention promptly.

Dosage & Administration of Dermasim VT 500

The adult dose of Clotrimazole for the treatment of vaginal vulvovaginal candidiasis (yeast infection) can vary depending on the severity of the infection and whether it's a first infection or a re-infection. Here are the recommended doses:

1. First Infections:

• Clotrimazole VT 100 or 1 Clotrimazole VT 200 vaginal tablet is inserted as deeply as possible into the vagina on three consecutive nights. This is the standard 3-day treatment for Candida vaginitis.

1. Re-infections:

Clotrimazole VT 100 vaginal tablet is inserted as deeply as possible into the vagina on six consecutive nights. This is the standard 6-day treatment for re-infections or mixed infections with the same causative organisms.

If necessary, you can use 2 Clotrimazole VT 100 tablets daily (1 in the morning and 1 in the evening) or 1 Clotrimazole VT 200 tablet daily for 6-12 days. This extended treatment may be required for more severe or recurrent infections.

It's essential to time the treatment to avoid the menstrual period and complete it before the onset of menstruation.

For prevention of re-infection, it's recommended that the partner undergo local treatment with Clotrimazole Cream at the same time.

Additionally, there is a single-dose option available:

• Clotrimazole VT 500 vaginal tablet is used as a single-dose complete treatment. The tablet should be inserted as deeply as possible into the vagina. This option can be convenient for some individuals who prefer a one-time treatment.

Administration:

• Vaginal Use Only: Dermasim VT 500 Tablet is intended for vaginal use only. It should not be swallowed or used for any other purposes.
• Correct Administration: The tablet should be inserted into the vagina, as high as possible, using the applicator provided. The best way to achieve this is by lying back with your legs bent up.
• Physician's Instructions: Your doctor will determine the appropriate dose and duration of treatment based on factors such as your age, body weight, and the severity of your condition.
• Seek Clarification: If you have any doubts or questions about the prescribed doses or how to use the medication, it's essential to consult your doctor for clarification.

As with any medication, it's crucial to follow the instructions provided by your healthcare provider or the product's label carefully. If you have any questions or concerns about the treatment, it's best to consult your doctor for personalized advice.

Interaction

Medicines used after an organ transplant: Examples include tacrolimus and sirolimus. These medications are immunosuppressants used to prevent rejection of transplanted organs. The use of antifungal medications like Dermasim VT 500 Tablet may interact with immunosuppressants, so it's important for your doctor to be aware of both medications to manage their interactions appropriately.

Latex contraceptives: If you are using latex contraceptives such as condoms or diaphragms for safe sex and to prevent pregnancy, you should inform your doctor. There is a possibility that Dermasim VT 500 Tablet or other vaginal medications may weaken latex, potentially reducing the effectiveness of these contraceptives. Your doctor can advise you on alternative contraceptive methods or the appropriate timing for using Dermasim VT 500 Tablet in relation to latex contraceptives.

Contraindications

If you are allergic to clotrimazole or any other ingredients of Dermasim VT 500 Tablet.

Pregnancy & Lactation

It is recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician.

Precautions & Warnings

• Vaginal Use Only: Dermasim VT 500 Tablet is intended for vaginal use only. It should not be swallowed and should be used as directed by your healthcare provider.
• Vaginal Intercourse: During the treatment with Dermasim VT 500 Tablet for a vaginal infection, it is recommended to avoid sexual intercourse. This is to reduce the risk of infecting your partner and to allow the medicine to work effectively.
• Use During Menstruation: Dermasim VT 500 Tablet should be avoided during menstruation. The menstrual flow may wash out the medicine, potentially reducing its effectiveness in treating the infection.
• Allergic Reactions: If you are allergic to clotrimazole or any of the other ingredients present in the medication, you should not use clotrimazole. Allergic reactions can range from mild skin irritation to severe allergic responses, and it's essential to avoid using the medication if you have known allergies.
• Pregnancy and Nursing: If you are pregnant or nursing, it's crucial to consult your doctor before using clotrimazole. The doctor will evaluate the potential risks and benefits and determine if clotrimazole is safe for use during pregnancy or while breastfeeding.
• Avoiding Other Topical Products/Medicines: When using clotrimazole, it's generally advised to avoid using any other topical products or medicines in the same area, unless specifically instructed by your healthcare provider. Combining multiple topical medications can lead to interactions or unintended side effects.
• Medical History and Other Medications: Before using clotrimazole, inform your doctor about your medical history, including any pre-existing conditions, allergies, or ongoing treatments. Additionally, disclose all other medications you are currently taking to avoid any potential negative interactions between clotrimazole and other drugs.

Storage Conditions

Store Dermasim VT 500 Tablet in a cool and dry below 25°C away from direct sunlight. Keep it out of the reach of children and pets.