Susten 30mg Tablet | ePharma
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Susten 30mg Tablet

Generic: Dapoxetine HCl

Type: Tablet

Pack Size: 10 Pcs

Not Available

Susten 30mg Tablet is a medicine used for the treatment of premature ejaculation (a sexual dysfunction in which a man ejaculates too quickly during sexual intercourse). This medicine helps in increasing the time taken to ejaculate and achieving better control over ejaculation during sexual intercourse.


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Discount Price: ৳ 279
MRP: ৳ 300 7% Off

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Description:

Susten 30mg Tablet contains Dapoxetine, a medication classified as a Selective Serotonin Reuptake Inhibitor, which is used to treat premature ejaculation. Premature ejaculation is a common condition where a man ejaculates too quickly with minimal sexual stimulation and before desire. It can be caused by hormonal imbalances, abnormal brain chemical levels, or infections, or diseases affecting the sexual organs.

Dapoxetine works by increasing the activity of serotonin, a chemical in the brain, which helps to delay ejaculation. This allows better control over ejaculation and enables the individual to hold back semen for a longer period of time. Before starting treatment, your doctor will conduct tests to determine if you are at risk of experiencing severe low blood pressure upon standing up.

It is recommended to take Susten 30mg Tablet at least 1-3 hours before engaging in sexual activity. Avoid consuming alcohol or grapefruit juice while using Susten 30mg Tablet. Inform your doctor about any history of bleeding disorders or mental disorders before taking the medication. It should not be used by individuals who do not have any sexual problems.

Susten 30mg Tablet is not suitable for patients with liver or heart problems, and it should not be used by children or adolescents under 18 years of age. If you experience dizziness upon sudden standing up or sudden mood changes or have suicidal thoughts after taking Susten 30mg Tablet, inform your doctor immediately. The most common side effects of Susten 30mg Tablet include dizziness, nausea, tiredness, increased sweating, restlessness, and decreased sex drive. If any of these side effects bother you, consult your doctor.

Safety Advices


Alcohol
UNSAFE

This medication may cause excessive drowsiness and calmness with alcohol.


Pregnancy
UNSAFE

Susten 30mg Tablet is not intended for use in women.


Breastfeeding
UNSAFE

Susten 30mg Tablet is not intended for use in women.


Driving
UNSAFE

Do not drive or operate any heavy tools or machines if you experience dizziness, fainting, or blurred vision after taking Susten 30mg Tablet.


Kidney
CONSULT YOUR DOCTOR

Susten 30mg Tablet should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.


Liver
CONSULT YOUR DOCTOR

There is no data available. Please consult a doctor before consuming the drug.

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Uses of Susten 30mg Tablet
  • Treats Premature Ejaculation in adult men (18 – 64 years of age)
How does Susten 30mg Tablet work?

Susten 30mg Tablet is the first medication designed exclusively to treat premature ejaculation. Although the precise mechanism of action is unknown, doctors believe it works by blocking the serotonin transporter (SERT) and preventing the re-uptake of 5-HT into neurons. Thus, increasing the availability of 5-HT at CNS receptors and increasing serotoninergic activity.

Side Effects of Susten 30mg Tablet
  • Nausea
  • Headache
  • Dizziness
  • Diarrhea
  • Blurred vision
  • Ringing or buzzing in the ears
  • Fast/irregular heartbeat
  • Increase in blood pressure
  • Excessive tiredness
  • Dry mouth
  • Anxiety
  • Abnormal dreams
  • Sleepiness
  • Nausea and vomiting
  • Erection problem
    Insomnia
  • Impotence
  • Loss Of Libido
Quick Suggestions:

Susten 30mg Tablet should be taken only 1 to 3 hours before anticipated sexual activity. It should not be taken more than once in a 24-hour period or on a daily basis. It is important to avoid activities that require concentration, such as driving, until you know how Susten 30mg Tablet affects you.

Caution should be exercised when using Susten 30mg Tablet in patients with a history of seizures, depression, or other psychiatric disorders. Maintaining a healthy weight, following a balanced diet, and engaging in regular exercise can help manage premature ejaculation. Pelvic floor exercises can strengthen the relevant muscles while using condoms can reduce penis sensitivity.

Spending intimate time with your partner, staying sexually active, and paying attention to your partner's needs are also important. Consuming foods that improve blood flow, such as onions, garlic, bananas, chili, and eggs, foods rich in omega-3 fatty acids and vitamin B1, as well as pepper, can be beneficial. Regular exercise can help reduce stress, and it is advised to avoid smoking and alcohol consumption.

Getting sunlight can increase melatonin levels, which can boost sexual desire. When taking Susten 30mg Tablet, it is recommended to take it with at least one full glass of water to minimize the chances of fainting due to its bitter taste. It should be taken 1 to 3 hours before sexual activity and not exceed more than one tablet within a 24-hour period.

Susten 30mg Tablet may cause a sudden drop in blood pressure, so it is advisable to rise slowly if you have been sitting or lying down. If you are suffering from erectile dysfunction, it is important to talk to your doctor before taking this medication.

Indication

Dapoxetine Hydrochloride is indicated for the treatment of premature ejaculation (PE) in men 18 to 64 years of age, who have all of the following:  

  • Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes.
  • Marked personal distress or interpersonal difficulty as a consequence of PE and poor control over ejaculation.
Pharmacology

The mechanism of action of Susten 30mg Tablet is believed to be related to the inhibition of serotonin reuptake in neurons, which leads to an increase in serotonin activity. Serotonin is a neurotransmitter involved in regulating various functions in the brain, including mood, emotions, and sexual activity.

The central ejaculatory neural circuit consists of a complex network of interconnected spinal and cerebral areas. This circuit is responsible for coordinating the process of ejaculation. Sensory genital and cerebral stimuli play a crucial role in activating this circuit.

Under the influence of these stimuli, the sympathetic, parasympathetic, and somatic spinal centers interact and integrate signals. This integration ultimately leads to the ejaculation response. By inhibiting serotonin reuptake, Susten 30mg Tablet modulates the activity of this neural circuit, potentially resulting in a delay in ejaculation and increased control over the timing of ejaculation.

It's important to note that the precise mechanisms underlying premature ejaculation and the effects of Susten 30mg Tablet are still areas of ongoing research and investigation.

Dosage & Administration of Susten 30mg Tablet

Susten 30mg Tablet can be taken with or without food. The tablet should be swallowed whole with a full glass of water. It should not be crushed or chewed.

  • For the treatment of premature ejaculation in adults aged 18-64 years, the initial dose is usually 30 mg, taken approximately 1-3 hours before sexual activity. The subsequent doses can be adjusted based on individual response, but the maximum recommended dose is 60 mg. It is important not to take more than one dose within a 24-hour period. The treatment should be reviewed after 4 weeks (6 doses) and then at least every 6 months thereafter.
  • In patients with moderate to severe hepatic impairment, Susten 30mg Tablet is contraindicated and should not be used.
  • For patients with renal impairment, no dose adjustment is necessary for those with mild or moderate impairment. However, caution should be exercised. Dapoxetine is not recommended for use in patients with severe renal impairment.

It is important to follow the instructions and dosage recommended by your physician. The timing of administration is generally 1-3 hours before anticipated sexual activity. The appropriate dose and duration of therapy will be determined by your doctor based on factors such as your age, body weight, and overall health condition.

Interaction

Susten 30mg Tablet can have potential serious reactions when used in combination with certain medications. Here are some important interactions to be aware of:

MAOIs: There is a risk of serious reactions when Susten 30mg Tablet is used with monoamine oxidase inhibitors (MAOIs). Concurrent use or use within 14 days of discontinuing MAOI treatment should be avoided.

Thioridazine: Susten 30mg Tablet inhibits the metabolism of thioridazine, which can lead to increased levels of thioridazine in the body. The use of Susten 30mg Tablet and thioridazine should be avoided.

Serotonergic Medicinal/Herbal Products: Susten 30mg tablet can increase the risk of serotonergic-associated effects when used with other medicinal or herbal products that have serotonergic effects. These include L-tryptophan, triptans, tramadol, linezolid, SSRIs, SNRIs, lithium, and St. John's wort preparations. Concurrent use or use within 14 days of discontinuing these products should be avoided.

CNS-Active Medicinal Products: Susten 30mg Tablet can interact with another central nervous system (CNS)-active medicinal products, potentially leading to additive effects. Caution should be exercised when using Susten 30mg Tablet in combination with these medications.

Inhibitors of CYP2D6, CYP3A4, and Flavin Monooxygenase 1: Susten 30mg Tablet may reduce the clearance of drugs metabolized by CYP2D6, CYP3A4, and flavin monooxygenase 1 enzyme. This can result in increased exposure to these medications.

Inhibitors of CYP3A4: The use of Susten 30mg Tablet with potent or moderate CYP3A4 inhibitors can increase the exposure of Dapoxetine in the body. Examples of potent CYP3A4 inhibitors include ketoconazole, itraconazole, ritonavir, and saquinavir. Examples of moderate CYP3A4 inhibitors include erythromycin, clarithromycin, fluconazole, and verapamil.

Reduced Orthostatic Tolerance: Susten 30mg Tablet may potentially reduce orthostatic tolerance when used with PDE-5 inhibitors (used for erectile dysfunction) and β-adrenergic receptor antagonists.

Interactions with other drugs: Susten 30mg Tablet can increase the plasma concentration of desipramine and other drugs that are metabolized by CYP2D6. It can also decrease the AUCinf (area under the concentration-time curve) of midazolam. Caution should be exercised when using Susten 30mg Tablet in combination with these medications.

Warfarin: Chronic therapy with warfarin (an anticoagulant) should be used with caution when taking Susten 30mg Tablet.

Alcohol: Consumption of alcohol should be avoided while using Susten 30mg Tablet, as it can increase the risk of adverse effects.

Contraindications
  • Known hypersensitivity (allergy) to dapoxetine hydrochloride or any of the other ingredients in the tablet.
  • Patients with significant pathological cardiac conditions, such as heart failure (NYHA class II-IV), conduction abnormalities (2nd- or 3rd-degree AV block or sick sinus syndrome) that are not treated with a permanent pacemaker, significant ischemic heart disease, or significant valvular disease.
  • Concomitant use of monoamine oxidase inhibitors (MAOIs) or use within 14 days of discontinuing MAOI treatment. Similarly, Dapoxetine should not be administered within 7 days after discontinuing MAOI treatment.
  • Concomitant use of thioridazine or use within 14 days of discontinuing thioridazine treatment. Similarly, thioridazine should not be administered within 7 days after discontinuing Dapoxetine treatment.
  • Concomitant use of serotonin re-uptake inhibitors (such as selective serotonin re-uptake inhibitors - SSRIs, serotonin-norepinephrine re-uptake inhibitors - SNRIs, tricyclic antidepressants - TCAs) or other medicinal/herbal products with serotonergic effects, or use within 14 days of discontinuing treatment with these products. Similarly, these medicinal/herbal products should not be administered within 7 days after discontinuing Dapoxetine treatment.
Pregnancy & Lactation

Dapoxetine is not recommended for women.

Precautions & Warnings
  • If you have allergies to any components of Susten 30mg Tablet or certain medical conditions, it is important not to take this medication.
  • These conditions include heart problems like heart failure or rhythm issues, severe depression or mania, moderate to severe liver problems, a history of fainting, and the use of certain medications such as MAO inhibitors, thioridazine, lithium, linezolid, tryptophan, tramadol, St. John's wort, antidepressants, and anti-migraine drugs.
  • Inform your doctor if you have erectile dysfunction, a history of low blood pressure-induced dizziness, depression, mania, bipolar disorder, schizophrenia, epilepsy, bleeding or blood clotting disorders, glaucoma, or kidney problems. Susten 30mg Tablet is not intended for use in women.
  • It can cause side effects such as dizziness, sleepiness, fainting, or blurred vision, so be cautious while driving.
  • It is advisable to avoid alcohol consumption as it may increase dizziness.
  • The safety and effectiveness of Susten 30mg Tablet have not been established in children below 18 years of age.
  • When getting up from a sitting or lying position, do so slowly as Susten 30mg Tablet may cause dizziness upon sudden standing.
  • This medication should not be used by men below 18 years or above 65 years of age.
Storage Conditions

Store below 30°C, away from light, in a cool, dry place. Keep out of children's reach.

Frequently Asked Questions (FAQ)

Yes, Susten 30mg Tablet is used to treat premature ejaculation in adult men aged between 18 and 64 years. Premature ejaculation is when a man ejaculates with minimal sexual stimulation and before he wants. This can cause problems for the man and may cause problems in sexual relationships.

Yes, Susten 30mg Tablet is safe if used at prescribed doses for the prescribed duration advised by your doctor.

Yes

You may experience sleeping problems and may feel dizzy if you stop taking Susten 30mg Tablet on your own. Therefore, consult your doctor before discontinuing the medicine.

Avoid taking Susten 30mg Tablet in combination with certain medications such as monoamine oxidase inhibitors (MAOIs), thioridazine (used for schizophrenia), lithium (used for mania), linezolid (an antibiotic), tryptophan (used as a sleep aid), tramadol (a pain reliever), St. John's wort (an herbal supplement for depression), antidepressants, and anti-migraine medications. It is important to wait for a 14-day interval before taking Susten 30mg Tablet if you have recently used any of these medications. Similarly, after discontinuing Susten 30mg Tablet, wait for at least 7 days before starting these medicines. If you have any concerns or questions about the interaction between Susten 30mg Tablet and other medications, it is recommended to consult your doctor.

Susten 30mg Tablet should be taken about 1-3 hours before anticipated sexual activity. Therefore, do not forget or miss to take your dose at the right time.

Yes. Susten 30mg Tablet delays the release of sperms (ejaculation) in patients suffering from premature ejaculation. It is not suitable for use in healthy patients without any sexual problems (such as erectile dysfunction or premature ejaculation).

Inform your doctor before taking Susten 30mg Tablet along with sildenafil or tadalafil. Your doctor would prescribe a combination of sildenafil or tadalafil with dapoxetine if you have both erection and ejaculation problems. Since the use of sildenafil/tadalafil with dapoxetine can increase the risk of orthostatic hypotension (feeling dizzy while standing up), you should consult your doctor before taking them together. Your doctor would also check whether you have any heart problems or taking medicines to lower blood pressure.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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