Methotrax 2.5 | Rheumatoid Arthritis | Psoriasis | Cancer | Anti-metabolites
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Methotrax 2.5mg Tablet

Generic: Methotrexate

Type: Tablet

Pack Size: 10 Pcs

Methotrexate is used to treat:

  • Active rheumatoid arthritis
  • Psoriasis
  • Arthritis in patients suffering from psoriasis (psoriatic arthritis)
  • Relapsed and refractory (unaffected by other conventional treatments) Non-Hodgkin’s Lymphoma
  • Polyarticular juvenile idiopathic arthritis

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Discount Price: ৳ 46.5
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Description:

Methotrax 2.5mg Tablet is a medication prescribed to address conditions such as rheumatoid arthritis, psoriasis, and certain cancers like choriocarcinoma, acute lymphoblastic leukemia, and lymphoma. Its mechanism involves suppressing the immune system to alleviate joint pain and swelling, as well as impeding the growth of cancer cells.

Administration of Methotrax 2.5mg Tablet can be done with or without food, and the tablet should be swallowed whole with water, avoiding crushing, breaking, or chewing. It is crucial to adhere to the prescribed dose and treatment duration as directed by the physician. Alcohol consumption during this medication is discouraged to mitigate undesirable effects, and discontinuation should only occur under the guidance of a doctor.

Individuals allergic to Methotrexate should avoid its use, and caution is warranted for those with liver conditions, weakened immune systems, alcohol use, or bone marrow disorders. Careful monitoring, including tests for complete blood cell count, liver function, and kidney function, may be recommended.

Pregnant individuals are advised against using Methotrax 2.5mg Tablet due to potential harm to the developing fetus. Effective contraception is recommended during its use to prevent pregnancy. Breastfeeding is also discouraged as the medication can pass into breast milk, posing potential risks to the nursing infant.

Safety Advices


Alcohol
UNSAFE

It is recommended to avoid the consumption of alcohol while taking Methotrax 2.5mg Tablet as it may increase the risk of liver damage. Consult your doctor before taking Methotrax 2.5mg Tablet.


Pregnancy
UNSAFE

Methotrax 2.5mg Tablet is not recommended for use if you are pregnant and/or are planning to become pregnant since it can be harmful to the fetus (growing baby) and lead to various malformations. Consult your doctor before taking Methotrax 2.5mg Tablet.


Breastfeeding
UNSAFE

Methotrax 2.5mg Tablet is not recommended if you are a nursing mother. Consult your doctor before taking Methotrax 2.5mg Tablet.


Driving
CAUTION

Methotrax 2.5mg Tablet is not recommended if you feel tired or dizzy after taking the medicine. Consult your doctor before taking Methotrax 2.5mg Tablet.


Kidney
CONSULT YOUR DOCTOR

Methotrax 2.5mg Tablet is not recommended if you have or had a kidney disorder and/or are receiving any dialysis treatment. Consult your doctor before taking Methotrax 2.5mg Tablet.


Liver
CONSULT YOUR DOCTOR

Methotrax 2.5mg Tablet is not recommended if you have a liver disorder. Consult your doctor before taking Methotrax 2.5mg Tablet.

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Uses of Methotrax 2.5mg Tablet
  • Choriocarcinoma
  • Rheumatoid Arthritis
  • Psoriasis
  • Acute lymphoblastic Leukaemia (ALL) and Lymphoma
How does Methotrax 2.5mg Tablet work?

Methotrax 2.5mg Tablet stops or reduces inflammation in rheumatoid arthritis by altering the body’s defenses. In psoriasis, it kills the cells in the skin, which are growing too quickly. It is these fast-growing cells, which cause the raised patches of skin in psoriasis.

Side Effects of Methotrax 2.5mg Tablet
  • Stomach discomfort
  • Mouth ulcers
  • Nausea
  • Drowsiness
  • Muscle pain
Quick Suggestions:
  • Drink plenty of liquids to stay hydrated while taking this medication.
  • Take folic acid if advised by your doctor. This will help lessen the side effects of this medicine.
  • It may take from weeks to months for Mtx 2.5mg Tablet to work. Keep taking the medication as prescribed.
  • Your doctor may get regular blood tests done to monitor your kidney function, liver function, and level of blood cells in your blood.
  • Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
  • It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
Indications

Methotrax 10mg Tablet is used in the treatment of rheumatoid arthritis and psoriasis.

Pharmacology

Methotrax 10mg Tablet inhibits the enzyme dihydrofolic acid reductase. This enzyme is essential for converting dihydrofolates into tetrahydrofolates, which are necessary as carriers of one-carbon groups in the synthesis of nucleotides and thymidylate. By interfering with this process, Methotrax 10 mg disrupts DNA synthesis, repair, and cellular replication.

Tissues that actively proliferate, such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa, and cells of the urinary bladder, are generally more sensitive to the effects of Methotrax 10 mg. When cellular proliferation in malignant tissues surpasses that of most normal tissues, Methotrax 10 mg may impede the growth of malignant cells without causing irreversible damage to normal tissues.

Dosage & Administration of Methotrax 2.5mg Tablet

Adult Dose:

Oral:

  • Rheumatoid arthritis: 7.5 mg once weekly, adjust if needed (up to 20 mg/week).
  • Crohn's disease: 12.5-22.5 mg once weekly for up to 1 year.
  • Psoriasis: 10-25 mg once weekly, adjust subsequent doses if needed.

Child Dosage:

For Polyarticular Juvenile Idiopathic Arthritis:

  • Initial dose: 10 mg/m² orally (PO) / intramuscularly (IM) / subcutaneously (SC) once a week.

For Meningeal Leukemia:

  • Less than 1 year: 6 mg intrathecally (IT) every 2-5 days.
  • 1-2 years: 8 mg IT every 2-5 days.
  • 2-3 years: 10 mg IT every 2-5 days.
  • Over 3 years: 12 mg IT every 2-5 days.

Renal Dose Adjustments:

In renal impairment based on creatinine clearance (CrCl):

  • 61-80 ml/min: 75% of the usual dose.
  • 51-60 ml/min: 70% of the usual dose.
  • 10-50 ml/min: 30-50% of the usual dose.
  • Less than 10 ml/min: Avoid use.

For intermittent hemodialysis:

  • Administer 50% of the usual dose at the normal dosing interval.

For continuous renal replacement therapy:

  • Administer 50% of the usual dose at the normal dosing interval.

The administration details for Methotrexate 2.5 MG Tablet are quite extensive. Here's a breakdown of the information:

Administration:

Oral (PO) Administration:

  • Best taken on an empty stomach.
  • May be taken with meals to reduce gastrointestinal discomfort.
  • Avoid taking milk-rich products.
Interaction

Drug-Drug Interactions: Methotrax 2.5mg Tablet may interact with:

  • Pain killers (celecoxib, acetaminophen, hydrocodone).
  • Anti-depressant (duloxetine).
  • Immunosuppressants (etanercept).
  • Anti-rheumatoid (adalimumab).
  • Antacid (esomeprazole).
  • Anti-malarial (hydroxychloroquine).

Drug-Food Interactions: Avoid consuming alcohol while on treatment with Methotrax 2.5mg Tablet.

Drug-Disease Interactions: Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anemia, liver problems due to alcohol abuse, or chronic liver disease.

Do not take Methotrax 2.5mg Tablet if you:
  • Are allergic to any of its components.
  • Have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anemia, liver problems due to alcohol abuse, or chronic liver disease.
  • Are pregnant or breastfeeding?
Pregnancy & Lactation

Pregnancy category X. Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Talk to your doctor before taking Methotrax 2.5mg Tablet if you:
  • Have or had liver or kidney problems.
  • Have ulceration in the stomach or bowels.
  • Are in poor general condition.
  • Have received any vaccinations or are due to have any vaccinations?
  • Have diabetes, ascites (fluid in the stomach area), lung problems, or fluid in the lungs.

Methotrax 2.5mg Tablet may cause dizziness and fatigue, so only drive if you are alert. Take it exactly as directed by the doctor, as it may lead to serious problems if not taken in the prescribed dose and duration. Stop taking Methotrax 2.5mg Tablet and consult your doctor immediately if you experience mouth sores, diarrhea, fever, dehydration, cough, bleeding, shortness of breath, signs of infection, or a skin rash.

Storage Conditions

Store below 30°C

Frequently Asked Questions (FAQ)

Methotrax 2.5mg Tablet is not recommended in children for the treatment of psoriasis and rheumatoid arthritis. However, FOLITRAX 2.5MG TABLET can be used with caution in children to treat polyarticular juvenile idiopathic arthritis. Your doctor will prescribe the right dose depends on your child’s age, body weight and health condition. Consult your doctor for advice before taking FOLITRAX 2.5MG TABLET.

Reduced folate levels in the blood can be a concern, as folate is essential for various bodily functions, including the formation of DNA and the production of red blood cells. Methotrexate, being a folate antagonist, can interfere with these processes, and monitoring is necessary to ensure that the medication is not causing adverse effects.

Methotrax 2.5mg Tablet may impact egg and sperm production, potentially causing birth defects. Women of childbearing potential and men using this medication should use effective contraception during treatment and for at least six months after stopping it. METHOTREXATE 2.5MG TABLET can also result in infertility. Male patients are advised to discuss the option of sperm preservation with their doctor before starting treatment.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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